Cytomegalovirus infection (congenital) (Cytomegalovirus)

Clinical criteria
At least one of the following five:

– Stillbirth
– Intrauterine growth retardation
– Fulminant cytomegalic inclusion disease (jaundice, hepatosplenomegaly, petechiae, multiple organ involvement) in a child
– Central nervous system findings (microcephaly, motor disability, chorioretinitis, cerebral calcifications) in a child
– Lethargy, respiratory distress or seizures in the immediate post-partum period

Laboratory criteria
At least one of the following three:
– Isolation of Cytomegalovirus (CMV) from urine (recommended specimen), saliva, throat swab, tissue or other specimen in an infant within the first three weeks of life
– Detection of CMV DNA by molecular diagnostic techniques in urine, blood, tissue or other specimen in an infant within the first three weeks of life
– Histopathological evidence of CMV inclusion disease from appropriate clinical specimen

Epidemiological criteria
NA

Case classification
A. Possible case
NA
B. Probable case¹
A child meeting the clinical criteria, born to a CMV seropositive mother
C. Confirmed case
Any person meeting the laboratory criteria

^{1. Laboratory confirmation should always be sought in probable cases of illness}

Current as of: 28 May 2018